Marie-Thérèse Ruf Selected Research

mycolactone

1/2022	Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity.
1/2022	Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.
1/2020	Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of Mycobacterium ulcerans.
11/2017	Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria.
1/2017	The Macrolide Toxin Mycolactone Promotes Bim-Dependent Apoptosis in Buruli Ulcer through Inhibition of mTOR.
4/2016	Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model.
2/2016	Interferon-γ Is a Crucial Activator of Early Host Immune Defense against Mycobacterium ulcerans Infection in Mice.
7/2015	Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions.
4/2013	Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.

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Marie-Thérèse Ruf Research Topics

Disease

17	Buruli Ulcer 01/2022 - 08/2011
8	Infections 01/2022 - 08/2011
6	Necrosis 01/2022 - 08/2011
4	Wounds and Injuries (Trauma) 01/2017 - 09/2011
3	Skin Diseases (Skin Disease) 01/2020 - 02/2016
2	Ischemia 01/2022 - 07/2015
2	Tuberculosis (Tuberculoses) 01/2020 - 02/2016
2	Ulcer 01/2017 - 04/2013
1	Neglected Diseases 01/2022
1	Leptospirosis 01/2022
1	African Trypanosomiasis (Nagana) 01/2020
1	Parasitic Diseases (Parasitic Disease) 12/2017
1	Body Weight (Weight, Body) 12/2017
1	Schistosomiasis (Bilharziasis) 12/2017
1	Purpura 07/2015
1	Fat Necrosis 07/2014
1	Hyperplasia 07/2014
1	Rupture 04/2013
1	Wiskott-Aldrich Syndrome 04/2013
1	Bacterial Infections (Bacterial Infection) 01/2013

Drug/Important Bio-Agent (IBA)

9	mycolactoneIBA 01/2022 - 04/2013
5	ExotoxinsIBA 01/2022 - 07/2015
4	MacrolidesIBA 01/2020 - 07/2015
4	AcidsIBA 04/2016 - 08/2011
3	Anti-Bacterial Agents (Antibiotics)IBA 12/2018 - 08/2011
3	VaccinesIBA 04/2016 - 02/2012
3	Streptomycin (Streptomycin Sulfate)FDA Link 04/2014 - 02/2012
3	Rifampin (Rifampicin)FDA LinkGeneric 04/2014 - 02/2012
2	FibrinIBA 01/2022 - 07/2015
2	Pharmaceutical PreparationsIBA 12/2018 - 12/2017
1	paraform (paraformaldehyde)IBA 01/2022
1	bafilomycin A1IBA 01/2022
1	phosphatidylinositol 3-phosphateIBA 01/2022
1	Blood Proteins (Serum Proteins)IBA 01/2022
1	CalciumIBA 01/2022
1	Carrier Proteins (Binding Protein)IBA 01/2022
1	Chloroquine (Aralen)FDA LinkGeneric 01/2022
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2022
1	Immunoglobulin M (IgM)IBA 01/2022
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022
1	Phosphates (Orthophosphate)IBA 01/2022
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	Thromboplastin (Tissue Factor)IBA 01/2022
1	UbiquitinIBA 01/2022
1	Prokaryotic Initiation Factor-2IBA 01/2022
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2022
1	Green Fluorescent ProteinsIBA 01/2022
1	Activating Transcription Factor 4IBA 01/2022
1	Cytotoxins (Cytolysins)IBA 01/2020
1	telacebecIBA 01/2020
1	Virulence Factors (Pathogenicity Factors)IBA 01/2020
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 12/2018
1	Praziquantel (Biltricide)FDA Link 12/2017
1	Ro 13-3978IBA 12/2017
1	Matrix Metalloproteinases (MMPs)IBA 01/2017
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	Biomarkers (Surrogate Marker)IBA 01/2017
1	GelatinasesIBA 01/2017
1	InterferonsIBA 02/2016
1	AnticoagulantsIBA 07/2015
1	ThrombomodulinIBA 07/2015
1	Keratin-16 (Keratin 16)IBA 04/2014
1	Proteins (Proteins, Gene)FDA Link 04/2013
1	LipidsIBA 04/2013

Therapy/Procedure

4	Drug Therapy (Chemotherapy) 01/2013 - 08/2011
2	Combination Drug Therapy (Combination Chemotherapy) 04/2014 - 02/2012
1	Aftercare (After-Treatment) 01/2020
1	Protective Clothing 01/2013
1	Debridement 09/2011
1	Therapeutics 08/2011